Immune imbalance mediates the relationship between plasma vitamin D concentration and preeclampsia in Chinese pregnant women: a case–control study
Our results provided preliminary evidence for a potential mediating role of the Th1/Th2 and Th17/Treg balance in the association between plasma 25(OH)D<sub>2</sub> and preeclampsia. Keeping higher levels of vitamin D, especially 25(OH)D<sub>2</sub> might help maintain the immune balance and decrease the risk of preeclampsia.
Authors
- Yuan Cao (ORCID: https://orcid.org/0000-0002-5635-9253)
- Yacong Bo (ORCID: https://orcid.org/0000-0001-7306-9971)
- Dandan Duan (ORCID: https://orcid.org/0000-0001-5145-9864)
- Huanan Chen
- Weifeng Dou
- Yanhua Liu (ORCID: https://orcid.org/0000-0003-4667-2083)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-5867-9322)
- Jinyan Liu (ORCID: https://orcid.org/0009-0003-2254-7998)
- Wenjun Fu (ORCID: https://orcid.org/0000-0003-0946-092X)
- Xianlan Zhao
- Jiaqi Nie
Institutions
- Zhongyuan University of Technology (CN)
- Zhengzhou University (CN)
- Third Affiliated Hospital of Zhengzhou University (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fnut.2025.1665593
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Nutrition Society
- National Natural Science Foundation of China