Development and Validation of a Type 1 Diabetes Multi-Ancestry Polygenic Score
Type 1 diabetes polygenic scores are highly predictive of disease risk, but their performance varies based on genetic ancestry. Can we develop a polygenic score that accurately predicts type 1 diabetes risk across diverse populations? Our novel polygenic score performs similar to existing scores in European populations, and it demonstrates superior performance in non-European populations. This polygenic score will improve prediction of type 1 diabetes risk in genetically diverse populations.
Authors
- Aaron J. Deutsch (ORCID: https://orcid.org/0000-0001-6750-5335)
- Alicia Huerta‐Chagoya (ORCID: https://orcid.org/0000-0001-6218-3904)
- Andrew S. Bell (ORCID: https://orcid.org/0000-0003-2497-9420)
- Ruth Nanjala (ORCID: https://orcid.org/0000-0002-8878-8685)
- Stella Nam (ORCID: https://orcid.org/0000-0002-9049-2680)
- Maggie Ng (ORCID: https://orcid.org/0000-0002-0656-3002)
- Alisa K. Manning (ORCID: https://orcid.org/0000-0003-0247-902X)
- Raymond J. Kreienkamp (ORCID: https://orcid.org/0000-0002-1683-323X)
- Yang Luo (ORCID: https://orcid.org/0000-0001-7385-6166)
- Alison A. Motsinger‐Reif (ORCID: https://orcid.org/0000-0003-1346-2493)
- Seth A. Sharp (ORCID: https://orcid.org/0000-0002-0607-9990)
- Miriam S. Udler (ORCID: https://orcid.org/0000-0003-3824-9162)
- Dominika A. Michalek (ORCID: https://orcid.org/0000-0002-0634-0319)
- Stephen S. Rich
- Adam Burkholder (ORCID: https://orcid.org/0000-0002-0237-6920)
- Suna Önengüt-Gümüşcü (ORCID: https://orcid.org/0000-0002-6563-8334)
- Ravi Mandla (ORCID: https://orcid.org/0000-0002-0782-0138)
- Josep M. Mercader (ORCID: https://orcid.org/0000-0001-8494-3660)
- Richard A. Oram
- Jose C. Florez
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Exeter (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- University of Oxford (GB)
- Massachusetts General Hospital (US)
- National Institute of Environmental Health Sciences (US)
- National Institute of Health (AM)
- Boston Children's Museum (US)
- Center for Genomic Science (IT)
- University of Virginia (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- Philadelphia University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-11-14
- DOI
- https://doi.org/10.2337/db25-0772
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00