Transplantation of mesenchymal stromal cell-derived mitochondria alleviates endothelial dysfunction in pre-clinical models of acute respiratory distress syndrome
This study demonstrated MSC mitochondrial transplantation as a promising therapeutic approach for treatment of endothelial dysfunction in the context of acute inflammation. Further exploration of mitochondrial transplantation in ARDS is warranted.
Authors
- Dayene de Assis Fernandes Caldeira (ORCID: https://orcid.org/0000-0002-4361-7524)
- Pedro Leme Silva (ORCID: https://orcid.org/0000-0001-5838-4949)
- Daniel Francis McAuley (ORCID: https://orcid.org/0000-0002-3283-1947)
- Johnatas D. Silva (ORCID: https://orcid.org/0000-0003-4379-4237)
- Anna Krasnodembskaya (ORCID: https://orcid.org/0000-0002-2380-5069)
- Fernanda Ferreira Cruz (ORCID: https://orcid.org/0000-0001-9443-3648)
- Rodrigo Gonzaga Veras (ORCID: https://orcid.org/0000-0003-4501-090X)
- Monique Martins Melo
- Patrícia R. M. Rocco (ORCID: https://orcid.org/0000-0003-1412-7136)
Institutions
- Queen's University Belfast (GB)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- National Institute of Science and Technology in Regenerative Medicine (BR)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1093/stcltm/szaf053
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Federal do Rio de Janeiro
- Medical Research Council