NEDD8-specific protease 1 deficiency as a novel driver of hepatoblastoma development through dysregulation of the CAND1–NEDD8 pathway
NEDP1 acts as a tumor suppressor in HB by modulating the NEDDylation status of key regulatory proteins, particularly CAND1. Restoration of NEDP1 activity suppresses tumorigenesis and metastasis, underscoring the NEDDylation pathway as a promising therapeutic target. CAND1 is proposed as a potential prognostic biomarker and actionable oncogenic driver in HB.
Authors
- José J.G. Marı́n (ORCID: https://orcid.org/0000-0003-1186-6849)
- Alfonso Castaneda
- Clàudia Gil‐Pitarch (ORCID: https://orcid.org/0000-0003-2220-0612)
- Bruce Wang (ORCID: https://orcid.org/0000-0003-3486-5494)
- Dimitris P. Xirodimas (ORCID: https://orcid.org/0000-0001-9275-1140)
- Matías A. Ávila (ORCID: https://orcid.org/0000-0001-6570-3557)
- Zbyněk Heger (ORCID: https://orcid.org/0000-0002-3915-7270)
- Rubén Nogueiras (ORCID: https://orcid.org/0000-0002-9976-9930)
- Pau Sancho‐Bru (ORCID: https://orcid.org/0000-0001-5569-9259)
- María Mercado-Gómez (ORCID: https://orcid.org/0000-0003-2765-6432)
- Naroa Goikoetxea‐Usandizaga (ORCID: https://orcid.org/0000-0003-4569-028X)
- Irene González‐Recio (ORCID: https://orcid.org/0000-0003-1432-8974)
- Marina Serrano‐Maciá (ORCID: https://orcid.org/0000-0003-4183-6384)
- Abhishek Murti (ORCID: https://orcid.org/0000-0003-0198-9933)
- Sofía Lachiondo‐Ortega (ORCID: https://orcid.org/0000-0003-1856-3664)
- Claudia M. Rejano-Gordillo (ORCID: https://orcid.org/0000-0003-4586-5975)
- Miguel Ángel Merlos Rodrigo (ORCID: https://orcid.org/0000-0002-1920-0948)
- Maitane Asensio (ORCID: https://orcid.org/0000-0002-8723-6053)
- Ugo Mayor (ORCID: https://orcid.org/0000-0003-2812-8287)
- Maria Luz Martínez‐Chantar (ORCID: https://orcid.org/0000-0002-6446-9911)
- Teresa C. Delgado (ORCID: https://orcid.org/0000-0001-9204-581X)
- Maite G. Fernández‐Barrena (ORCID: https://orcid.org/0000-0003-0375-6236)
- Álvaro Del Río-Álvarez (ORCID: https://orcid.org/0000-0003-2338-0782)
- Carolina Armengol (ORCID: https://orcid.org/0000-0002-4690-4027)
- Diego F. Calvisi (ORCID: https://orcid.org/0000-0002-6038-8567)
- Jon Ander Barrenechea-Barrenechea (ORCID: https://orcid.org/0009-0007-5972-6796)
- L. Estefanía Zapata-Pavas
- Patricia Peña-Sanfélix
- Hana Michalkova
- Elise Lelou
Institutions
- Ikerbasque (ES)
- Centre National de la Recherche Scientifique (FR)
- University of the Basque Country (ES)
- University of California, San Francisco (US)
- Universidad de Salamanca (ES)
- Université de Montpellier (FR)
- Universidade de Santiago de Compostela (ES)
- Instituto de Salud Carlos III (ES)
- Navarre Institute of Health Research (ES)
- CIC bioGUNE (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Biomédica de Salamanca (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Mendel University in Brno (CZ)
- University of Regensburg (DE)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Hepatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1097/hep.0000000000001614
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00