INHBA promotes chemoresistance in pancreatic cancer by enhancing CTPS1 stability and mediating pyrimidine metabolism
INHBA promotes gemcitabine resistance in PC by stabilizing CTPS1 and enhancing pyrimidine metabolism, making it a potential target for chemosensitization in PC.
Authors
- Zhi Wei (ORCID: https://orcid.org/0000-0001-6059-4267)
- Yanyu Gong
- Zhiwei He (ORCID: https://orcid.org/0000-0002-1434-2170)
- Dijie Zheng
- Xiaozhao Han (ORCID: https://orcid.org/0000-0001-7356-5959)
- Fei Ran Li (ORCID: https://orcid.org/0000-0002-2455-4986)
- Chao Yu (ORCID: https://orcid.org/0000-0002-8525-5920)
- Liwen Chen (ORCID: https://orcid.org/0000-0002-7271-2467)
- Xiangxiang Liao (ORCID: https://orcid.org/0009-0009-6850-9675)
- Xu Sun
- Suye Ran
Institutions
- Guiyang Medical University (CN)
- Shenzhen University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12935-025-03984-8
- Primary Topic
- Biochemical and Molecular Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00