Downregulation of the cysE/cysK genes of Clostridioides difficile induced by cysteine revealed the response of bacteria to iron homeostasis
Different reference strains of C. difficile and clinical isolates had different doses and durations of responsiveness to cysteine addition, and the critical link involved the availability of iron in the environment of the bacteria. This is possibly the response of bacteria to the regulation of gene expression through the maintenance of iron homeostasis.
Authors
- Yuan Wu (ORCID: https://orcid.org/0000-0002-9436-5929)
- Feng Liao (ORCID: https://orcid.org/0000-0002-2446-215X)
- Yongming Zhou
- Wenpeng Gu (ORCID: https://orcid.org/0000-0002-1960-538X)
- Jianwen Yin
- Wenzhu Zhang (ORCID: https://orcid.org/0000-0001-7040-3268)
- Lulu Bai (ORCID: https://orcid.org/0000-0002-8163-2071)
- Xiaoqing Fu (ORCID: https://orcid.org/0009-0007-8267-8761)
- Senquan Jia
Institutions
- Kunming Medical University (CN)
- First People's Hospital of Yunnan Province (CN)
- Yunnan Center for Disease Control And Prevention (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12866-025-04490-7
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China