Predictors of low-level viremia in chronic hepatitis B and the efficacy of pegylated interferon-alpha: a real-world study
Age, baseline HBV DNA level, HBsAg level, and HBeAg status were independently associated with the prevalence of LLV independently. Compared to NAs monotherapy, IFNα-based combination therapy in LLV patients demonstrated significantly higher rates of CVR, HBsAg decline, HBsAg loss/seroconversion, and HBeAg loss.
Authors
- Nana Xie
- Wenjin Sun
- Jianxin Song (ORCID: https://orcid.org/0000-0002-4090-6670)
- Fangbing Tian
- Wenyuan Zhang
- Jia Chen (ORCID: https://orcid.org/0000-0003-4217-5039)
- Qiurong Ruan (ORCID: https://orcid.org/0000-0002-7015-7666)
- Wencong Zhang
Institutions
- Ezhou Central Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Virology Journal
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12985-025-02981-7
- Citations
- 1
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35