The Neurogenic Inflammation Mediator Endothelin‐1 Causes Human Skin Barrier Disruption in Atopic Dermatitis via an <scp>ETAR</scp> / <scp>TRPA1</scp> ‐Axis
Our findings suggest that a neurogenic inflammation axis ET-1/ETAR/TRPA1 contributes to skin barrier impairment in AD by repressing differentiation markers and tight junction proteins. Additionally, we demonstrate ETAR-blockage as a rational therapeutic modality for patients with AD.
Authors
- Shahd M. Younis (ORCID: https://orcid.org/0009-0005-3742-3554)
- Sara Mohamed A.M. AlHarami (ORCID: https://orcid.org/0000-0003-4300-0556)
- Ayda AlHammadi (ORCID: https://orcid.org/0009-0000-1459-0281)
- Maha Victor Agha (ORCID: https://orcid.org/0000-0002-2807-0364)
- Martin Steinhoff (ORCID: https://orcid.org/0000-0002-7090-2187)
- Jianghui Meng (ORCID: https://orcid.org/0000-0002-3107-4200)
- Joerg Buddenkotte (ORCID: https://orcid.org/0000-0002-2394-3269)
- Rari Leo (ORCID: https://orcid.org/0000-0002-2276-6395)
- Majid Alam (ORCID: https://orcid.org/0000-0002-5783-6605)
- Ahmed Ali Al-Qahtani (ORCID: https://orcid.org/0000-0003-4584-5739)
- Anh Jochebeth (ORCID: https://orcid.org/0000-0003-2517-8772)
- Angeliki Datsi (ORCID: https://orcid.org/0000-0001-5022-8087)
- Fareed Ahmad (ORCID: https://orcid.org/0000-0003-2827-8744)
- Nabeel Abdulrahman (ORCID: https://orcid.org/0000-0002-2451-7536)
- Febu Elizabeth Joy (ORCID: https://orcid.org/0009-0004-6906-9783)
Institutions
- Cornell University (US)
- Düsseldorf University Hospital (DE)
- Weill Cornell Medical College in Qatar (QA)
- Dublin City University (IE)
- Weill Cornell Medicine (US)
- Heinrich Heine University Düsseldorf (DE)
- Hamad Medical Corporation (QA)
- Qatar University (QA)
Publication Details
- Journal
- Allergy
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/all.70149
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00