Application of an individualized nomogram in the first-trimester for predicting cleft lip and palate
The nomogram model integrating NT ≥ 2.5 mm, FMFA, CRL, and IFA demonstrates superior diagnostic performance for the first-trimester predicting of CLP compared with individual markers. Given its reliance on routinely measured parameters and ease of use, this model offers a practical, non-invasive, and efficient tool that may facilitate early detection of CLP in the first trimester of pregnancy.
Authors
- Qihong Li (ORCID: https://orcid.org/0000-0002-0356-6160)
- Yi‐Huang Hong
- Xiaocen Yang
- Biao Li (ORCID: https://orcid.org/0000-0002-7971-0085)
- Xiaoli Chen (ORCID: https://orcid.org/0000-0001-6835-7768)
- Shu Huang
- Lixuan Chen (ORCID: https://orcid.org/0000-0002-0333-7990)
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12884-025-08274-9
- Primary Topic
- Cleft Lip and Palate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00