miR-629-3p affects postmenopausal osteoporosis through targeted regulation of BACH1
miR-629-3p attenuates OP progression by inhibiting BACH1, thereby promoting osteoblast survival, proliferation, and differentiation. Its diagnostic potential and therapeutic role in restoring osteogenic function highlight miR-629-3p/BACH1 as a promising axis for OP management. However, the findings of this study require further validation in animal models to fully establish causality.
Authors
- Jing Xiao (ORCID: https://orcid.org/0000-0001-9615-4749)
- Yun Dong
- Caifeng Yan (ORCID: https://orcid.org/0000-0002-0203-9756)
- Jinxiang Zhang (ORCID: https://orcid.org/0000-0002-5447-272X)
- S. K. Ha
Institutions
- Nantong University (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Wuhan No.1 Hospital (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Baise University (CN)
- Wuhan No.9 Hospital (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13018-025-06413-8
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00