AMSC-EVs attenuate acute kidney injury through TXNIP-IKKα/NFκB signaling-mediated renal CX3CR1+ macrophage polarization
Our study findings suggest that AMSC-EVs modulate the polarization of renal CX3CR1<sup>+</sup> macrophages and promote renal self-recovery following cisplatin-induced AKI through the TXNIP-IKKα/NFκB signaling pathway.
Authors
- Changchun Cao (ORCID: https://orcid.org/0000-0003-1992-4257)
- Rui Tang (ORCID: https://orcid.org/0000-0002-6950-9580)
- Meng-qing Ma (ORCID: https://orcid.org/0000-0002-4024-6684)
- Weijuan Deng
- Hao Zhang (ORCID: https://orcid.org/0009-0006-9483-834X)
Institutions
- Jiujiang First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13287-025-04754-z
- Citations
- 2
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Health Commission of Jiangxi Province
- Youth Science Foundation of Jiangxi Province