Exploration of the roles of CAFs in melanoma based on single-cell transcriptomics and spatial transcriptomics
Through spatial aggregation and multifaceted immune signaling, CAF constructs a multilayered immune-exclusion network in melanoma, linking stromal remodeling to immune evasion. These findings offer novel insights into CAF-driven immune resistance and may inform future stratified immunotherapeutic strategies.
Authors
- Sheng Chiong Hong (ORCID: https://orcid.org/0000-0001-8954-1433)
- Yan Rong
- Zukai Li
- Lude Zhu
- Anming Hu (ORCID: https://orcid.org/0000-0001-9794-0549)
- Yuhan Zhao (ORCID: https://orcid.org/0000-0002-2507-1601)
- Yuming Li (ORCID: https://orcid.org/0000-0002-9948-5110)
- Weike Su (ORCID: https://orcid.org/0000-0003-2544-1948)
- Yizhong Zhang (ORCID: https://orcid.org/0000-0003-3035-3037)
Institutions
- Wannan Medical College (CN)
- Second Military Medical University (CN)
- Anhui Medical University (CN)
- Hong Kong University of Science and Technology (HK)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1007/s12672-025-03868-3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Hospital Development Center