Causal links between congenital malformations, birth weight, and neuroblastoma: insights from Mendelian randomization
Genital organ malformations confer protection against both overall and 11q-deleted neuroblastoma, whereas urinary system, gallbladder, biliary and liver malformations increase risk exclusively for 11q-deleted disease. However, due to the relaxed p-value threshold used for instrument selection, these findings should be interpreted cautiously and warrant replication with stricter criteria.
Authors
- Shui-Xue Li
- Munire Aierken
- Falide Atabieke (ORCID: https://orcid.org/0009-0006-9862-4277)
- Yierzhati Aizezi
- Ling Zhou (ORCID: https://orcid.org/0000-0001-5442-7999)
- Ailikamu Aierken
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12887-025-06295-z
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00