Detect early TB infection, evaluate contacts for TB (DETEC-TB) – a protocol for a prospective cohort study on active case finding for tuberculosis disease and tuberculosis infection source tracing
The DETEC-TB study proposes a novel approach to active tuberculosis case finding and infection source tracing. Serial T-SPOT.TB testing of adolescents will detect prevalent and incident TB infections. Close contacts of these adolescents will be tested to identify cases of infectious TB disease that may have transmitted the infection.
Authors
- Lulu Said Fundikira (ORCID: https://orcid.org/0000-0002-4953-7699)
- Mecky Matee (ORCID: https://orcid.org/0000-0002-6900-1533)
- Maryam Amour (ORCID: https://orcid.org/0000-0002-2590-2516)
- Emmanuel Balandya (ORCID: https://orcid.org/0000-0002-3707-9985)
- George Mugambage Ruhago (ORCID: https://orcid.org/0000-0001-7469-7822)
- Candida Moshiro (ORCID: https://orcid.org/0000-0001-7606-2361)
- Patricia Munseri (ORCID: https://orcid.org/0000-0002-8754-2755)
- Jackline E Ngowi (ORCID: https://orcid.org/0000-0002-2540-615X)
- Petra Joseph
- C. Robert Horsburgh (ORCID: https://orcid.org/0000-0001-6838-7895)
- Christopher C. Whalen
- C. Fordham von Reyn
- A Issa
Institutions
- Dartmouth College (US)
- Boston University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- University of Georgia (US)
- Boston Public Schools (US)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12879-025-11797-3
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases