Does polypharmacy affect epigenetic aging in older people? Evidence from a longitudinal epigenome-wide methylation study
These findings suggest an influence of polypharmacy on accelerated epigenetic aging and on altered methylation patterns in the genome, suggesting a potential implication of pathways related to renal tissue development, lipoproteins and cholesterol homeostasis, inflammatory and immune response, in line with previous proteomic analyses of polypharmacy mouse models. These observations also suggest potential targets for mitigating disruptive effects of polypharmacy on elderly health.
Authors
- Livia Rago (ORCID: https://orcid.org/0000-0002-0763-4730)
- Mariarosaria Persichillo (ORCID: https://orcid.org/0000-0002-9731-0173)
- Deodato Assanelli (ORCID: https://orcid.org/0000-0002-0286-9493)
- M. Muñoz (ORCID: https://orcid.org/0000-0002-9832-3523)
- Fabrizia Noro (ORCID: https://orcid.org/0000-0002-4754-9303)
- Martina Morelli
- Simona Costanzo (ORCID: https://orcid.org/0000-0003-4569-1186)
- Emilia Ruggiero (ORCID: https://orcid.org/0000-0002-7109-1128)
- Augusto Filippo Di Castelnuovo (ORCID: https://orcid.org/0000-0001-9767-7998)
- Danilo Licastro (ORCID: https://orcid.org/0000-0001-8372-9355)
- Chiara Cerletti (ORCID: https://orcid.org/0000-0002-4759-3179)
- Licia Iacoviello (ORCID: https://orcid.org/0000-0003-0514-5885)
- Stefania Falciglia
- Simona Esposito (ORCID: https://orcid.org/0000-0002-6123-3372)
- Margherita Degasperi (ORCID: https://orcid.org/0000-0002-4234-3795)
- Americo Bonanni (ORCID: https://orcid.org/0000-0001-5736-169X)
- Anwal Ghulam (ORCID: https://orcid.org/0000-0001-7550-325X)
- Alfonsina Tirozzi (ORCID: https://orcid.org/0000-0002-6052-1807)
- Marialaura Bonaccio (ORCID: https://orcid.org/0000-0002-8082-6552)
- Teresa Panzera (ORCID: https://orcid.org/0000-0003-2048-296X)
- Antonietta Pepe (ORCID: https://orcid.org/0000-0002-3407-9752)
- Antonio Gioacchino Spagnolo (ORCID: https://orcid.org/0000-0002-5762-2164)
- Miriam Shasa Quiccione
- Francesco Gianfagna (ORCID: https://orcid.org/0000-0003-4615-0816)
- Francesca Bracone
- Sabatino Orlandi (ORCID: https://orcid.org/0000-0002-9498-173X)
- Sara Magnacca (ORCID: https://orcid.org/0000-0003-0379-040X)
- Alessandro Gialluisi (ORCID: https://orcid.org/0000-0002-7388-4463)
- Giovanni de Gaetano (ORCID: https://orcid.org/0000-0002-7823-1402)
- Amalia De Curtis (ORCID: https://orcid.org/0000-0001-5104-0318)
- Jos Vermylen
- Renzo Pegoraro
- Maria Benedetta Donati
- Alisia Cretella
- Concetta Civitillo
Institutions
- University of Insubria (IT)
- Libera Università Maria SS. Assunta (IT)
- University of Molise (IT)
- AREA Science Park (IT)
- Istituto Neurologico Mediterraneo (IT)
- LUM Jean Monnet University (IT)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13148-025-02007-7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Regione Molise