Dynamic tumor-infiltrating lymphocytes predicts survival in HR+/HER2− early breast cancer: a pre-to-post neoadjuvant chemotherapy study
In HR+/HER2- eBC, elevated pre-treatment TILs are independently associated with inferior survival outcomes, while chemotherapy-induced TILs reduction in residual disease correlates with significant prognostic improvement.
Authors
- Chuan Wang (ORCID: https://orcid.org/0000-0003-2000-9179)
- Wenhui Guo
- Yuxiang Lin (ORCID: https://orcid.org/0000-0002-3963-3468)
- Peng He (ORCID: https://orcid.org/0000-0002-7779-5265)
- Qindong Cai
- Yali Wang (ORCID: https://orcid.org/0000-0002-1739-3053)
- Long Wu (ORCID: https://orcid.org/0009-0007-5977-4747)
- Shunyi Liu
- Renren Zhang
- Weifeng Cai
- Yibin Qiu
- Jie Zhang (ORCID: https://orcid.org/0009-0004-5173-9996)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Cancer Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13058-025-02150-2
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Natural Science Foundation of Fujian Province
- Fujian Medical University