Distinct Effects of Complement <scp> <i>C4A</i> </scp> and <scp> <i>C4B</i> </scp> Copy Numbers in Systemic Sclerosis Serological and Clinical Subtypes
This study highlights distinct genetic contributions of C4A and C4B in SSc subtypes susceptibility. Our findings suggest that lower C4 CNs, particularly C4A, increase the risk of the severe dcSSc subtype, potentially through a mechanism involving immune complex clearance.
Authors
- Javier Martínez‐López (ORCID: https://orcid.org/0000-0003-0184-9543)
- Martin Kerick (ORCID: https://orcid.org/0000-0002-6298-4514)
- Jeska K de Vries‐Bouwstra (ORCID: https://orcid.org/0000-0002-5624-1415)
- Mandana Nikpour (ORCID: https://orcid.org/0000-0002-6585-5611)
- José Luís Callejas-Rubio (ORCID: https://orcid.org/0000-0002-1653-0087)
- Susanna Proudman (ORCID: https://orcid.org/0000-0002-3046-9884)
- Shervin Assassi (ORCID: https://orcid.org/0000-0002-8059-9978)
- Maureen D. Mayes (ORCID: https://orcid.org/0000-0001-5070-2535)
- Gianluca Moroncini (ORCID: https://orcid.org/0000-0002-0380-0105)
- Marialbert Acosta‐Herrera (ORCID: https://orcid.org/0000-0002-9868-6535)
- Nicolas Hunzelmann
- Yannick Allanore (ORCID: https://orcid.org/0000-0002-6149-0002)
- Marta E. Alarcón‐Riquelme (ORCID: https://orcid.org/0000-0002-7632-4154)
- Ariane L. Herrick (ORCID: https://orcid.org/0000-0003-4941-7926)
- Lorenzo Beretta (ORCID: https://orcid.org/0000-0002-6529-6258)
- Carmen Pilar Simeón‐Aznar (ORCID: https://orcid.org/0000-0003-3390-9029)
- Alfredo Guillén-Del-Castillo
- Javier Martín (ORCID: https://orcid.org/0000-0001-5326-7081)
- Inmaculada Rodriguez‐Martin (ORCID: https://orcid.org/0000-0001-5413-1581)
- Christopher P. Denton (ORCID: https://orcid.org/0000-0003-3975-8938)
- Carlos Rangel‐Peláez (ORCID: https://orcid.org/0000-0001-7697-1696)
Institutions
- Marche Polytechnic University (IT)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- The University of Melbourne (AU)
- University of Cologne (DE)
- University of Zurich (CH)
- Université Paris Cité (FR)
- Manchester Academic Health Science Centre (GB)
- Leiden University Medical Center (NL)
- The Royal Free Hospital (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- UNSW Sydney (AU)
- Sorbonne Paris Cité (FR)
- Manchester University NHS Foundation Trust (GB)
- University Hospital of Zurich (CH)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Instituto de Parasitología y Biomedicina "López - Neyra" (ES)
- The University of Texas Health Science Center (US)
- University College London (GB)
- The University of Adelaide (AU)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1002/art.43433
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Federation of Pharmaceutical Industries and Associations
- National Institute for Health and Care Research
- Department of Health and Social Care
- European Commission
- Ministerio de Ciencia e Innovación
- Universidad de Granada
- Manchester Biomedical Research Centre
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- European Social Fund