Early-Onset of Obesity Model: Impact of Early-Onset Obesity on Comorbidity Risk and Life Expectancy
The model and these scenarios underscore the predicted substantially detrimental effects of early-onset and prolonged obesity on life expectancy, and the increased risks of obesity-related comorbidities. They suggest that morbidity and mortality risks increase with obesity duration and severity in a nonlinear manner, thereby supporting the view that early weight-loss intervention and obesity prevention strategies may reduce long-term health risks substantially.
Authors
- Anthony Peter Goldstone (ORCID: https://orcid.org/0000-0001-8179-7071)
- Luis Alberto Moreno (ORCID: https://orcid.org/0000-0003-0454-653X)
- I. Sadaf Farooqi (ORCID: https://orcid.org/0000-0001-7609-3504)
- Peter Kühnen (ORCID: https://orcid.org/0000-0003-0211-176X)
- Thomas M. Barber (ORCID: https://orcid.org/0000-0003-0689-9195)
- Dénes Molnár (ORCID: https://orcid.org/0000-0002-3675-7019)
- Karine Clément (ORCID: https://orcid.org/0000-0002-2489-3355)
- Erica L T van den Akker (ORCID: https://orcid.org/0000-0001-5352-9328)
- Andrea Maria Haqq (ORCID: https://orcid.org/0000-0002-6256-4982)
- Claude Marcus (ORCID: https://orcid.org/0000-0003-0890-2650)
- Evan P. Nadler (ORCID: https://orcid.org/0000-0001-8312-4647)
- Christine Poitou (ORCID: https://orcid.org/0000-0001-7769-6331)
- Martin Wabitsch (ORCID: https://orcid.org/0000-0001-6795-8430)
- Nicolas Touchot
- Jan Luca Schorfheide
- Urs Wiedemann
Institutions
- University of Alberta (CA)
- Inserm (FR)
- George Washington University (US)
- Universität Ulm (DE)
- University of Cambridge (GB)
- Universidad de Zaragoza (ES)
- Instituto de Salud Carlos III (ES)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Hammersmith Hospital (GB)
- Erasmus MC (NL)
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- Karolinska Institutet (SE)
- Humboldt-Universität zu Berlin (DE)
- University of Warwick (GB)
- Sorbonne Université (FR)
- Nutrition et obésité : approches systémiques (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Jazz Pharmaceuticals (United States) (US)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Pitié-Salpêtrière Hospital (FR)
- German Centre for Cardiovascular Research (DE)
- Instituto de Investigación Sanitaria Aragón (ES)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- European Patent Organisation (DE)
- Rhythm (United states) (US)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Pecs (HU)
Publication Details
- Journal
- Obesity Facts
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1159/000549499
- Citations
- 1
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.49