Defining the early systemic neutrophil signature after severe trauma: decreased CD10/CD16 levels on admission precedes metabolic dysregulation
This study shows that admission CD10 and CD16 expression levels on neutrophils correlate with elevated lactate levels 8 h post-injury in severe polytrauma. A specific CD10/CD16 neutrophil signature, linked to leukocytosis, precedes metabolic dysregulation, determined by higher lactate levels. A better understanding of the early neutrophil receptor profile may form the basis for future immunomonitoring and guide treatment decisions.
Authors
- Emma de Fraiture
- Falco Hietbrink (ORCID: https://orcid.org/0000-0003-1462-6840)
- Leo Koenderman (ORCID: https://orcid.org/0000-0002-5636-6453)
- Yannik Kalbas (ORCID: https://orcid.org/0000-0002-1550-328X)
- Michel Teuben (ORCID: https://orcid.org/0000-0003-0310-4668)
- Felix Karl-Ludwig Klingebiel (ORCID: https://orcid.org/0000-0002-6438-5208)
- Hans‐Christoph Pape (ORCID: https://orcid.org/0000-0002-2059-4980)
- Paolo Cinelli (ORCID: https://orcid.org/0000-0002-0163-9055)
- Roman Pfeifer (ORCID: https://orcid.org/0000-0003-1543-3995)
- Christian Thomas Hübner (ORCID: https://orcid.org/0009-0003-9285-8660)
- Nathalie Piaz
Institutions
- University Medical Center Utrecht (NL)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- European Journal of Trauma and Emergency Surgery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1007/s00068-025-02980-x
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00