Pediococcus acidilactici attenuates chronic stress-induced depression via generating metabolite indole-3-lactic acid and downregulating neuroinflammation
Pediococcus acidilactici CGMCC 35671 metabolizes tryptophan to produce ILA, which crosses the blood-brain barrier via systemic circulation to activate the AHR pathway, thereby attenuating neuroinflammation and ameliorating depressive symptoms.
Authors
- Kexin Geng
- Yuan Tian (ORCID: https://orcid.org/0000-0003-0192-3037)
- Jun Gong (ORCID: https://orcid.org/0000-0002-4402-1263)
- Silu Zhang
- Jie Pan
- Yang Cong (ORCID: https://orcid.org/0000-0002-8888-3746)
- Mengzhen Jia (ORCID: https://orcid.org/0000-0002-2458-3023)
- Rongrong Wu (ORCID: https://orcid.org/0000-0003-4140-4637)
- Yuhao Wang (ORCID: https://orcid.org/0000-0002-4539-3720)
- Zhigang Liu (ORCID: https://orcid.org/0000-0002-6863-6561)
- Xia Chen (ORCID: https://orcid.org/0000-0003-3732-073X)
Institutions
- Shenzhen University (CN)
- North West Agriculture and Forestry University (CN)
- Microbiology Institute of Shaanxi (CN)
- Shenzhen Hanke Bioengineering (China) (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12974-025-03580-7
- Citations
- 8
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.62
Funders
- National Natural Science Foundation of China
- Shenzhen Fundamental Research Program
- Basic and Applied Basic Research Foundation of Guangdong Province