The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis
Our findings reveal a novel role for VCPKMT as a regulator of ferroptosis sensitivity in CRC, highlighting the VCPKMT-VCP-HDAC1 axis as a potential therapeutic target for CRC treatment.
Authors
- Dan Xie (ORCID: https://orcid.org/0000-0002-2769-9179)
- Fengwei Wang (ORCID: https://orcid.org/0000-0003-3886-7331)
- Yongrui Lv
- Jinghua Cao
- Shuidan Xu
- Jiewei Chen
- Cijun Huang
- Jinlong Lin
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12935-025-04044-x
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China