Downregulation of p120 catenin in the mouse hippocampus contributes to the development of depression-like phenotypes
These findings suggest that p120 may function to prevent the development or expression of depressive symptoms by suppressing proinflammatory NF-κB-IL-1β signaling in the hippocampus. Targeting p120 may be a feasible therapeutic strategy to treat MDD.
Authors
- Qi Wang (ORCID: https://orcid.org/0000-0003-0734-3383)
- Ruifang Hua (ORCID: https://orcid.org/0000-0002-4041-334X)
- Luwen Zhang (ORCID: https://orcid.org/0000-0002-8876-3947)
- Xi Su (ORCID: https://orcid.org/0000-0003-3235-8114)
- Laipeng Feng
- Qing Liu (ORCID: https://orcid.org/0000-0001-5286-4423)
- Peiling Shi
- Chen Chen (ORCID: https://orcid.org/0000-0003-0000-5920)
- Wenqiang Li (ORCID: https://orcid.org/0009-0002-2593-0194)
Institutions
- Henan Psychiatric Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12993-025-00305-x
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southeast University
- Xinxiang Medical University