Integrative Mendelian randomization and spatial transcriptomics analysis reveals causal links between plasma lipidome and non–small cell lung cancer
This study reveals a causal link between distinct plasma lipid species and NSCLC risk, emphasizing the role of lipid structural diversity. PVT1 may act as a critical mediator connecting lipid dysregulation to lung tumorigenesis, offering novel biomarker and therapeutic target potential.
Authors
- Lu Zhou (ORCID: https://orcid.org/0009-0001-8695-6606)
- Lijun Miao (ORCID: https://orcid.org/0000-0001-6524-256X)
- Baiquan Zhang
- Jintao Liu (ORCID: https://orcid.org/0000-0002-7014-6262)
- Qian Guo (ORCID: https://orcid.org/0000-0002-8622-8553)
- Huanqin Wang (ORCID: https://orcid.org/0000-0001-8531-5279)
Institutions
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1007/s12672-025-03823-2
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China