Up-regulated WNT5A in PCOS affects steroidogenesis, proliferation and apoptosis of granulosa cells through the PI3K/AKT pathway
WNT5A inhibits steroidogenesis via the PI3K/AKT pathway in granulosa cells. Our findings suggest that increased WNT5A may be attributed to inflammation and may result in endocrine dysregulation in PCOS patients.
Authors
- Ying Tan (ORCID: https://orcid.org/0000-0002-8139-5758)
- Zhijian Huang (ORCID: https://orcid.org/0000-0002-8241-0761)
- Zhen Liu (ORCID: https://orcid.org/0000-0001-5338-7219)
- Ying Chen (ORCID: https://orcid.org/0000-0002-4252-3331)
- Yizhe Li (ORCID: https://orcid.org/0009-0004-1193-7007)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13048-025-01779-z
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chongqing Medical University
- Natural Science Foundation of Chongqing