MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway
This study demonstrates that Ox-mtDNA drives MASH progression by promoting macrophage pyroptosis via the ITPR3/Ca²⁺/NLRP3 axis, providing a novel therapeutic strategy for targeted intervention.
Authors
- Shengwei Li (ORCID: https://orcid.org/0000-0002-1647-1363)
- Xinyi Wu
- Qi Zhang (ORCID: https://orcid.org/0009-0004-4089-4552)
- Tao Liu (ORCID: https://orcid.org/0000-0001-5232-5964)
- Li Chen (ORCID: https://orcid.org/0000-0002-4907-9720)
- Rui Wang (ORCID: https://orcid.org/0000-0001-8346-5783)
- Junyan Liu (ORCID: https://orcid.org/0009-0004-9048-9088)
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Dali University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12967-025-07302-8
- Citations
- 4
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22