RNA-sequencing-based elucidation of the mechanism underlying aFGF mediated regulation of BMSCs via the PI3K-AKT pathway and its implications for rotator cuff injury repair
aFGF modulated the differential gene expression in BMSCs by activating the PI3K-AKT signaling pathway, thereby promoting BMSCs' proliferation, migration, angiogenesis, and osteogenic differentiation. This mechanism provides a novel theoretical basis and potential therapeutic targets for rotator cuff injury management.
Authors
- Zhichuan Jiang
- Changlian Lu (ORCID: https://orcid.org/0000-0002-0812-9162)
- Daifeng Lu
- Haonan Liu (ORCID: https://orcid.org/0000-0001-8989-7173)
- Xin Guo (ORCID: https://orcid.org/0000-0002-9658-1887)
- Xiaowei Liu (ORCID: https://orcid.org/0000-0003-4298-6720)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13018-025-06431-6
- Citations
- 2
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Harbin Medical University