Lactate and gastric cancer immunotherapy from regulatory mechanisms to therapeutic strategies: a critical review
This review elucidates the dual roles and clinical value of lactate in gastric cancer as both an energy substrate and a signalling molecule within the tumour microenvironment and positions lactylation as a critical metabolic-epigenetic bridge. We also discuss innovative strategies that integrate lactate metabolism-targeting immune checkpoint inhibitors to overcome therapeutic resistance in GC.
Authors
- Yuxiang Yue (ORCID: https://orcid.org/0000-0003-1171-1126)
- Yumei Hao (ORCID: https://orcid.org/0000-0002-6074-5202)
- Manli Cui (ORCID: https://orcid.org/0000-0001-7860-2472)
- Qian Li (ORCID: https://orcid.org/0000-0003-4657-1020)
- Yanan Zhang (ORCID: https://orcid.org/0000-0001-9792-0935)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-6744-8243)
- Chao Sun (ORCID: https://orcid.org/0000-0003-4423-5285)
- Mingxin Zhang (ORCID: https://orcid.org/0000-0002-3945-3387)
- Dan Ren (ORCID: https://orcid.org/0000-0003-0204-6144)
- Duo Yang
- Q.X. Fan
Institutions
- Tianjin Medical University General Hospital (CN)
- Xi'an Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s40001-025-03383-9
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Education Department of Shaanxi Province