Exploring hemoglobin dynamics and scavenging mechanisms in preterm infants and preterm rabbits with cerebral intraventricular hemorrhage
The aim of this study was to characterize the dynamics of hemoglobin and haptoglobin in the cerebrospinal fluid of preterm infants with severe IVH and to evaluate the translational validity of a preterm rabbit pup IVH model. By directly comparing hemoglobin and haptoglobin concentrations across species, this study revealed a profound imbalance between hemoglobin burden and scavenging capacity, highlighting a persistent deficit in endogenous clearance. These findings provide a strong rationale for therapeutic strategies targeting hemoglobin clearance in preterm IVH and support the use of the rabbit pup IVH model for translational studies.
Authors
- Kirsten Guse
- Niklas Ortenlöf
- Suvi Vallius
- Amanda Kristiansson (ORCID: https://orcid.org/0000-0003-2898-7129)
- Claes Ekström (ORCID: https://orcid.org/0000-0001-6635-5822)
- Thomas Gentinetta (ORCID: https://orcid.org/0009-0004-9470-9877)
- Magnus Gram (ORCID: https://orcid.org/0000-0002-5880-2925)
- Valérie Verdon
- Markus Brechmann
- Helena Karlsson
- David Ley (ORCID: https://orcid.org/0000-0002-7498-6883)
- Sandra Mena Perez
- Katarzyna Wiatrowska
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Malmö University (SE)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Swiss Institute for Regenerative Medicine (CH)
- Skåne University Hospital (SE)
- CSL (Switzerland) (CH)
- University of Gothenburg (SE)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1038/s41390-025-04556-2
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- CSL Behring
- Lunds Universitet
- Vetenskapsrådet
- Skånes universitetssjukhus