A new biological enhancement therapy for anterior cruciate ligament reconstruction: the preclinical proof of anterior cruciate ligament reconstruction with tendon graft reseeded with autologous anterior cruciate ligament-derived cells
Implantation of a tendon graft reseeded with culture-expanded ACL-derived cells, and ACLM powder enhanced the tendon graft's maturation process and mechanical properties. We provide in vitro and in vivo proof-of-concept evidence supporting the efficacy of reseeding a tendon graft with ACL-derived cells combined with ACLM powder as a biological scaffold for ACL reconstruction.
Authors
- Yoon‐Kwan Jang
- Khalid Alkhelaifi (ORCID: https://orcid.org/0000-0002-4560-441X)
- Myung-Kyu Lee (ORCID: https://orcid.org/0000-0003-0922-5233)
- Tae-Hwan Kim
- Young Seok Lee (ORCID: https://orcid.org/0000-0002-0217-2661)
- Jin Kyu Lee (ORCID: https://orcid.org/0000-0001-8547-4616)
- J.H. Park (ORCID: https://orcid.org/0000-0002-1281-0428)
- Tae‐Jin Kim (ORCID: https://orcid.org/0000-0001-7678-0478)
- Hyunsung Kim (ORCID: https://orcid.org/0000-0002-8935-7414)
- Hyunsoo Soh (ORCID: https://orcid.org/0000-0001-7435-2728)
Institutions
- Qatar Orthopaedic and Sports Medicine Hospital (QA)
- Hanyang University Seoul Hospital (KR)
- Hanyang University (KR)
- Pusan National University (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13287-025-04760-1
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea