A Comparison of Clinical, Neonatal, and Maternal Factors Between Early- and Late-Onset Group B Streptococcal Disease

Differences in epidemiology and clinical manifestations of EOGBS and LOGBS support different approaches to prevent each entity. Strategies for EOGBS prevention include maternal antibiotic prophylaxis and maternal screening. The transmission and pathogenesis of LOGBS are likely different than EOGBS, creating a need for different preventative strategies. Potential mechanisms to prevent LOGBS include maternal vaccination.