Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus
This study demonstrates the utility of early-pregnancy metabolomic profiling for predicting GDM in Indian women. The eight-metabolite panel offers a promising tool for early risk stratification of GDM, warranting validation in diverse populations.
Authors
- Dandamudi Usharani (ORCID: https://orcid.org/0000-0001-5728-9421)
- Kuppan Gokulakrishnan (ORCID: https://orcid.org/0000-0003-3167-8239)
- Anu Raghunathan (ORCID: https://orcid.org/0000-0002-7063-9606)
- Priyanka Narad (ORCID: https://orcid.org/0000-0001-7317-654X)
- Payal Gupta
- Jerzy Adamski (ORCID: https://orcid.org/0000-0001-9259-0199)
- Ponnusamy Saravanan (ORCID: https://orcid.org/0000-0002-9566-2626)
- Muthuswamy Balasubramanyam
- Dharmeshkumar Parmar (ORCID: https://orcid.org/0000-0001-7956-7429)
- Venkateswarlu Panchagnula (ORCID: https://orcid.org/0000-0001-6441-2598)
- S Sreedevi
- Abhishek Sengupta (ORCID: https://orcid.org/0000-0002-3958-3675)
- Sapna Sharma (ORCID: https://orcid.org/0000-0003-1039-8879)
- Uma Ram
- Mohan Deepa
- RanjitMohan Anjana
- Viswanathan Mohan
- Ansh Tandon
- Y V Subrahmanyam
- Sangeetha Vadivel
Institutions
- Central Food Technological Research Institute (IN)
- University of Ljubljana (SI)
- National University of Singapore (SG)
- Amity University (IN)
- George Eliot Hospital (GB)
- Helmholtz Zentrum München (DE)
- National Chemical Laboratory (IN)
- Indian Council of Medical Research (IN)
- University of Warwick (GB)
- Madras Diabetes Research Foundation (IN)
- Dr. Mohan's Diabetes Specialities Centre (IN)
- Seethapathy Clinic and Hospital (IN)
- National Institute of Mental Health and Neurosciences (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12933-025-02978-0
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arthritis National Research Foundation
- Wellcome Trust
- National Research Foundation
- Department of Biotechnology, Ministry of Science and Technology, India
- The Wellcome Trust DBT India Alliance
- Medical Research Council
- Science and Engineering Research Board