Prognostic utility of macrophage polarization (CD68/CD163 ratio) in Egyptian JAK2 positive myeloproliferative neoplasm patients: a single center study
TAM polarization, reflected by the CD68/CD163 ratio, is a prognostic marker in MPNs, particularly for thrombosis and fibrotic progression. These findings support integrating TAM profiling into routine histopathology and suggest macrophage-targeted therapies as potential strategies for MPN management.
Authors
- Mohamed Yehia (ORCID: https://orcid.org/0000-0002-0461-4507)
- Aya Mohammed Adel Arafat
- Shirihan Mahmoud Anwar Mahgoub
Institutions
- Cairo University (EG)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13000-025-01727-x
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cairo University
- Science and Technology Development Fund