DO PARENTS AND PATIENTS WITH EARLY-ONSET SCOLIOSIS (EOS) SHARE THE SAME PERSPECTIVE ON HEALTH-RELATED QUALITY OF LIFE? A COMPARISON OF EOSQ-24 AND SRS-22 SCORES

EOSQ-24 is validated in EOS patients aged 0-18 years and SRS-22 is validated in idiopathic scoliosis patients ≥10 years. EOSQ-24 is completed by the parent and SRS-22 is completed by the patient. A prior study comparing patient-reported outcome measures completed by older pediatric patients and their parents showed a low level of agreement. The aims of this study were (1) compare EOSQ-24 and SRS-22 scores completed at the same timepoint, and (2) compare EOSQ-24 and SRS-22 scores completed at subsequent timepoints, in patients aged 5-18 years with idiopathic or congenital scoliosis without developmental delay. This was a multicenter retrospective study. We identified pairs of EOSQ-24 and SRS-22 completed on the same day or within 6 months. Some patients had multiple pairs of surveys over time. EOSQ-24 and SRS-22 questions were matched using previously published methodology and domain scores for Pain, Function, Mental Health, and Satisfaction were compared. Patients with a change in treatment between completed surveys were excluded. Pearson Correlation test was used to compare EOSQ-24 and SRS-22 domain scores, with r>0.7 indicating a strong relationship. Four hundred and eleven pairs of EOSQ-24 and SRS-22 questionnaires were completed on the same day by 228 patients (Table 1). A strong correlation was found only for the Pain domain (r=0.77). Function, Mental Health, and Satisfaction domains had positive but not strong correlations (r= 0.58, r=0.50, r=0.41, respectively). Sub-analysis based on age also showed a strong correlation only for Pain (Table 2). There were 134 pairs of surveys with SRS-22 completed within 6 months after an EOSQ-24 by 76 patients (Table 1). All domains demonstrated a positive but not strong correlation, with Pain showing the highest correlation (r=0.64). EOSQ-24 and SRS-22 had a strong correlation only for the Pain domain when completed at the same timepoint. EOSQ-24 and SRS-22 completed within six months lacked a strong correlation for all domains. Our findings suggest that parents and older children with EOS may not share the same perspective on their health. Self-reported questionnaires may be more appropriate instruments to assess HRQoL in older, developmentally neurotypical patients with EOS. Future studies should further investigate how to compare proxy measures and self-reported outcome measures, as children with EOS develop cognitively with age and transition from parent-reported to self-reported questionnaires. For any figures or tables, please contact the authors directly.