Adjuvant metronomic tegafur-uracil is associated with poorer outcomes and unfavorable histopathologic progression in oral squamous cell carcinomas
Adjuvant metronomic UFUR provided no survival advantage and was associated with unfavorable histopathologic evolution in OSCCs. These findings warrant re-evaluation of UFUR as routine adjuvant therapy and support risk-adapted, molecularly guided postoperative strategies in oral cancer management.
Authors
- Kai-Feng Hung (ORCID: https://orcid.org/0000-0002-2144-5055)
- Chien‐Cheng Chen (ORCID: https://orcid.org/0000-0003-4346-6292)
- Peter Mu-Hsin Chang
- Yi-Chen Sun (ORCID: https://orcid.org/0000-0002-3247-0774)
- Yi‐Ping Wang (ORCID: https://orcid.org/0000-0001-9574-2194)
- Julia Yu‐Fong Chang (ORCID: https://orcid.org/0000-0002-3880-3787)
- Zhi-Qian Lin (ORCID: https://orcid.org/0009-0004-4138-6269)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Tzu Chi University (TW)
- Taipei Veterans General Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Dental Sciences
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1016/j.jds.2025.10.023
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00