Using protease inhibitors to prevent intraperitoneal adhesions: effects of nafamostat mesylate, UAMC-00050, GM6001, and enoxaparin in the cecal ligation and puncture model and the ischemic button model
Enoxaparin and NFM reduced adhesions effectively, suggesting that coagulation inhibition plays a key role. These findings suggest that selective protease inhibitors, when administered in a timely manner, could reduce intraperitoneal adhesions.
Authors
- Ingrid De Meester (ORCID: https://orcid.org/0000-0002-3421-0124)
- Koen Augustyns (ORCID: https://orcid.org/0000-0002-5203-4339)
- Benedicte Y. De Winter (ORCID: https://orcid.org/0000-0003-0327-6304)
- Joris De Man
- Philip Plaeke (ORCID: https://orcid.org/0000-0003-2794-3570)
- Michelle De bruyn (ORCID: https://orcid.org/0000-0002-7915-4445)
- Gun‐Soo Hong (ORCID: https://orcid.org/0000-0002-8780-3505)
- Philippe G. Jorens (ORCID: https://orcid.org/0000-0002-5434-957X)
- Sven Wehner (ORCID: https://orcid.org/0000-0002-8632-7631)
- Guy Hubens (ORCID: https://orcid.org/0000-0001-9854-7343)
- Joerg C. Kalff
Institutions
- University of Antwerp (BE)
- University Hospital Bonn (DE)
- Antwerp University Hospital (BE)
Publication Details
- Journal
- Surgery Today
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1007/s00595-025-03166-z
- Primary Topic
- Intestinal and Peritoneal Adhesions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- Universiteit Antwerpen