Novel Phenotypic Clusters of Youth-Onset Type 2 Diabetes Offer No Added Prognostic Value to Simple Clinical Measures
Youth-onset type 2 diabetes can be characterized into reproducible clusters that demonstrate differential response to treatments and risk of complications. Nevertheless, cluster membership did not add clinical utility beyond simple clinical measures for predicting outcomes.
Authors
- Aaron J. Deutsch (ORCID: https://orcid.org/0000-0001-6750-5335)
- Shylaja Srinivasan (ORCID: https://orcid.org/0000-0002-8049-6370)
- Toni I. Pollin (ORCID: https://orcid.org/0000-0002-6402-746X)
- Anna Bellatorre (ORCID: https://orcid.org/0000-0002-5414-0741)
- Ralph B. D’Agostino (ORCID: https://orcid.org/0000-0002-3550-8395)
- Catherine Pihoker (ORCID: https://orcid.org/0000-0001-9074-7770)
- Raymond J. Kreienkamp (ORCID: https://orcid.org/0000-0002-1683-323X)
- AMY SANGHAVI SHAH (ORCID: https://orcid.org/0000-0001-7297-139X)
- José C. Florez (ORCID: https://orcid.org/0000-0002-1730-9325)
- Lawrence M. Dolan (ORCID: https://orcid.org/0000-0002-5359-0636)
- Łukasz Szczerbiński (ORCID: https://orcid.org/0000-0002-6201-0605)
- Elizabeth T. Jensen (ORCID: https://orcid.org/0000-0003-2704-6634)
- Miriam S. Udler (ORCID: https://orcid.org/0000-0003-3824-9162)
- Kirk Smith (ORCID: https://orcid.org/0000-0002-4338-4812)
- Steven D. Gage
- Dana Dabelea (ORCID: https://orcid.org/0000-0001-9514-8929)
- Thinley Yidzin Wangden
Institutions
- Broad Institute (US)
- University of Maryland, Baltimore (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Medical University of Białystok (PL)
- University of California, San Francisco (US)
- Massachusetts General Hospital (US)
- Seattle Children's Hospital (US)
- Boston Children's Museum (US)
- Wake Forest University (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-11-14
- DOI
- https://doi.org/10.2337/dc25-1765
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00