Effectiveness of a multidisciplinary collaborative management model in the control of hospital-acquired infections caused by multidrug-resistant organisms

Hospital-acquired infections caused by multidrug-resistant organisms (MDROs) increase patient morbidity and healthcare costs. This study assessed a multidisciplinary collaborative management model to improve infection control and reduce MDRO rates. We conducted a retrospective cohort study at a tertiary hospital in Beijing from January 2021 to December 2024. Adult inpatients (≥18 years, length of stay ≥ 48 h) with complete clinical and microbiological data were included. Patients hospitalized before implementation of the multidisciplinary collaborative management model (January 2021-December 2022) comprised the control group, while those admitted after its launch (January 2023-December 2024) formed the intervention group. A multidisciplinary team - including infection control specialists, pharmacists, microbiologists, nursing staff, and ICU leadership - conducted twice-weekly ward rounds and supervised infection prevention practices. Compliance indicators, MDRO detection rates, and infection incidence were compared between groups. Compliance with infection control measures improved significantly after implementation (e.g., training 78.3% → 97.5%, environmental cleaning 83.3% → 95.7%, PPE use 86.4% → 93.8%; all P < .001). The MDRO detection rate decreased from 60.1 to 52.5% (χ2 = 43.5, P < .001). Overall MDRO infection incidence declined from 0.05 to 0.02% (χ2 = 9.18, P = .003), with marked reductions in ICU and emergency department intensive care units. Implementation of a multidisciplinary collaborative management model significantly enhanced compliance with infection control measures and reduced MDRO prevalence and infection incidence, particularly in critical care units. This approach provides a practical strategy for strengthening hospital infection control programs.