Glioblastoma with cerebrospinal fluid dissemination and MYC gene amplification: A transitional or atypical glioblastoma with primitive neuronal components

Based on this case and a review of relevant literature, it can be inferred that MYC amplification may serve as an early predictive biomarker for ECM via CSF dissemination in GBM. Furthermore, MYC gene overexpression may promote the transformation of primitive cells, and this case may represent a transitional or atypical GBM-PNC. This case suggests that clinicians should remain vigilant for the potential of CSF dissemination and ECM in GBM patients, particularly when MYC amplification is present, which could serve as an early warning of distant metastasis.