The mediating role of blood metabolites in the association between myocardial infarction and cancer risk: An observational and mendelian randomization analysis

Our integrative analysis suggests that myocardial infarction may be associated with a reduced cancer incidence through potential alterations in blood metabolite profiles, including dihomo-γ-linolenic acid, alpha-tocopherol, and inosine. These findings provide preliminary evidence that warrants further large-scale studies to validate the observed associations and to elucidate the underlying mechanisms.