Prognostic significance of neoadjuvant gemcitabine and S-1 chemotherapy with or without concurrent radiation in patients with resectable and borderline resectable pancreatic cancer: A post hoc analysis of 2 phase II trials
Although this study was a retrospective post hoc analysis of 2 phase II trials, which represents a major limitation, neoadjuvant chemotherapy with concurrent radiotherapy possibly improve survival compared with chemotherapy alone by suppressing local recurrence through a powerful local antitumor effect of radiation.
Authors
- Yutaka Takeda (ORCID: https://orcid.org/0000-0002-5504-994X)
- Takehiro Noda (ORCID: https://orcid.org/0000-0002-6768-5783)
- Shogo Kobayashi (ORCID: https://orcid.org/0000-0003-2305-942X)
- Hidetoshi Eguchi
- Shinichiro Hasegawa
- Yoshito Tomimaru
- Hirofumi Akita
- Daisaku Yamada
- Yuichiro Doki
- Kazuki Sasaki (ORCID: https://orcid.org/0000-0002-7138-9231)
Institutions
- Osaka Gakuin University (JP)
- Osaka City University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Surgery
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1016/j.surg.2025.109864
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science