Fibroblast-Mediated MMP2 Contribution to Nonresponse in Anti-TNFα Therapy for Crohn’s Disease
This study highlights the association of pathogenic fibroblasts and ECM remodeling in anti-TNFα therapy failure, identifies MMP2 as a potential target, and suggests that combination therapy may offer a potential strategy for patients with treatment resistance.
Authors
- Yao Zhang (ORCID: https://orcid.org/0000-0003-1174-7049)
- Dehao Zhu (ORCID: https://orcid.org/0009-0007-2229-1004)
- Haiming Zhuang (ORCID: https://orcid.org/0000-0002-3542-3236)
- Duowu Zou (ORCID: https://orcid.org/0000-0002-2029-8831)
- Xiangyu Zhao (ORCID: https://orcid.org/0000-0001-7760-0512)
- Danshu Wang (ORCID: https://orcid.org/0009-0003-9197-7692)
- Jiaxin Wang (ORCID: https://orcid.org/0000-0001-7033-7854)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1093/ibd/izaf263
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00