A fibroblast‐specific miRNA functional cluster in remote exosomes aggravates myocardial ischaemia/reperfusion injury via the Rap1b/ERK1/2 axis
Exosomes from non-ischaemic fibroblasts worsen I/R injury by promoting apoptosis of ischaemic cardiomyocytes through a cluster of miRNAs targeting the Rap1b/ERK1/2 pathway, highlighting Rap1b restoration as a potential therapeutic strategy.
Authors
- Jianping Bin
- Yulin Liao (ORCID: https://orcid.org/0000-0001-5961-390X)
- Wangjun Liao (ORCID: https://orcid.org/0000-0002-1364-8442)
- Cankun Zheng (ORCID: https://orcid.org/0000-0002-0815-646X)
- Jiarui Jin (ORCID: https://orcid.org/0000-0002-3551-8112)
- Mingjue Li
- Rongzhan Lin
- Hailin Zhu (ORCID: https://orcid.org/0000-0002-5391-9294)
- Tong Zhang (ORCID: https://orcid.org/0000-0002-0423-7414)
- Zhihong Li (ORCID: https://orcid.org/0000-0002-1944-9671)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-8664-6915)
- Xiaoxia Huang (ORCID: https://orcid.org/0000-0001-6566-0649)
- Mingyuan He (ORCID: https://orcid.org/0000-0002-1146-616X)
- Qiancheng Wang (ORCID: https://orcid.org/0000-0002-4842-6540)
- Xuemei Fu (ORCID: https://orcid.org/0000-0003-1070-8021)
- Hairuo Lin (ORCID: https://orcid.org/0000-0003-0413-3807)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Ganzhou People's Hospital (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/bph.70249
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81