Informative simultaneous confidence intervals for graphical test procedures

Simultaneous confidence intervals that are compatible with a given closed test procedure are often non-informative. More precisely, for a one-sided null hypothesis, the bound of the simultaneous confidence interval can stick to the border of the null hypothesis, irrespective of how far the point estimate deviates from the null hypothesis. This has been illustrated for the Bonferroni-Holm and fall-back procedures, for which alternative simultaneous confidence intervals have been suggested, that are free of this deficiency. These informative simultaneous confidence intervals are not fully compatible with the initial multiple test, but are close to it and hence provide similar power advantages. They provide a multiple hypothesis test with strong family wise error rate control that can be used in replacement of the initial multiple test. The current paper extends previous work for informative simultaneous confidence intervals to graphical test procedures. The information gained from the newly suggested simultaneous confidence intervals is shown to be always increasing with increasing evidence against a null hypothesis. The new simultaneous confidence intervals provide a compromise between information gain and the goal to reject as many hypotheses as possible. The simultaneous confidence intervals are defined via a family of dual graphs and the projection method. A simple iterative algorithm for the computation of the intervals is provided. A simulation study illustrates the results for a complex graphical test procedure.

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Journal
Statistical Methods in Medical Research
Published
2025-11-14
DOI
https://doi.org/10.1177/09622802251393666
Primary Topic
Statistical Methods in Clinical Trials
Type
article
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article

Informative simultaneous confidence intervals for graphical test procedures

Martin Scharpenberg, Werner Brannath, Liane Kluge
Statistical Methods in Medical Research
Statistical Methods in Clinical Trials
article

Informative simultaneous confidence intervals for graphical test procedures

Martin Scharpenberg, Werner Brannath, Liane Kluge
article en

Abstract

Simultaneous confidence intervals that are compatible with a given closed test procedure are often non-informative. More precisely, for a one-sided null hypothesis, the bound of the simultaneous confidence interval can stick to the border of the null hypothesis, irrespective of how far the point estimate deviates from the null hypothesis. This has been illustrated for the Bonferroni-Holm and fall-back procedures, for which alternative simultaneous confidence intervals have been suggested, that are free of this deficiency. These informative simultaneous confidence intervals are not fully compatible with the initial multiple test, but are close to it and hence provide similar power advantages. They provide a multiple hypothesis test with strong family wise error rate control that can be used in replacement of the initial multiple test. The current paper extends previous work for informative simultaneous confidence intervals to graphical test procedures. The information gained from the newly suggested simultaneous confidence intervals is shown to be always increasing with increasing evidence against a null hypothesis. The new simultaneous confidence intervals provide a compromise between information gain and the goal to reject as many hypotheses as possible. The simultaneous confidence intervals are defined via a family of dual graphs and the projection method. A simple iterative algorithm for the computation of the intervals is provided. A simulation study illustrates the results for a complex graphical test procedure.

Statistical Methods in Medical ResearchVol. 35(1)
University of Bremen (DE)
Openalex Percentile: Top 68%
Statistical Methods in Clinical Trials
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Informative simultaneous confidence intervals for graphical test procedures — Martin Scharpenberg, Werner Brannath, et al. · Statistical Methods in Medical Research (2025) | TGRS Research Map | TGRS