Long‐Term Attenuation of Vascular Hyperpermeability in a Hereditary Angioedema Mouse Model by Adenine Base Editing
These findings demonstrate that, in a murine model, NG-ABE8e-mediated disruption of Klkb1 enables durable suppression of serum kallikrein and vascular stabilization, suggesting its potential as a promising single-intervention strategy for the treatment of HAE.
Authors
- Huijun Yuan (ORCID: https://orcid.org/0000-0002-4173-7688)
- Yang Wang (ORCID: https://orcid.org/0000-0002-7466-4032)
- Yijun Lü (ORCID: https://orcid.org/0000-0002-1247-6597)
- Wei Wang (ORCID: https://orcid.org/0000-0002-2216-2575)
- Yuqing He (ORCID: https://orcid.org/0000-0001-5067-1169)
- Juan Meng (ORCID: https://orcid.org/0000-0001-8495-1388)
- Yaozhong Kong (ORCID: https://orcid.org/0000-0002-9178-6023)
- Y L Zhang (ORCID: https://orcid.org/0000-0002-0715-0744)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Allergy
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1111/all.70152
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 0.00