Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention
Our study elucidates the mechanisms underlying CA-induced neuroinflammation and identifies the IL-17 A pathway as a potential therapeutic target for mitigating neurological injury following cardiac arrest.
Authors
- Shumei Li
- Lianhong Zou (ORCID: https://orcid.org/0000-0002-0964-7447)
- Xiehong Liu (ORCID: https://orcid.org/0000-0002-1059-790X)
- Maiying Fan
- Yixiao Xu (ORCID: https://orcid.org/0000-0001-9524-4830)
- Lei Wang (ORCID: https://orcid.org/0000-0003-2402-2338)
- Yiyuan Zhang
- Qiqi Luo (ORCID: https://orcid.org/0000-0002-1438-6157)
Institutions
- Hunan Normal University (CN)
- Hunan Mawangdui Hospital (CN)
- Hunan Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12974-025-03600-6
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hunan Province