B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape
B7-H3 is a promising immunotherapy target in MM. B7-H3-specific and dual-targeting nanoCAR T cells could offer a strategy to prevent antigen escape and improve treatment durability.
Authors
- Eline Menu (ORCID: https://orcid.org/0000-0002-0805-6581)
- Karin Vanderkerken (ORCID: https://orcid.org/0000-0002-2137-7179)
- Dorien Autaers
- Vincenzo Raimondi (ORCID: https://orcid.org/0000-0002-9870-7893)
- Arne Van der Vreken (ORCID: https://orcid.org/0000-0003-0345-721X)
- Rosanna Vescovini
- Holly Lee (ORCID: https://orcid.org/0000-0001-8353-0848)
- Elke De Bruyne
- Paola Storti (ORCID: https://orcid.org/0000-0001-8014-8205)
- Heleen Hanssens (ORCID: https://orcid.org/0000-0001-8996-4671)
- Karine Breckpot (ORCID: https://orcid.org/0000-0003-4331-3480)
- Lorenzo Franceschini (ORCID: https://orcid.org/0000-0001-9013-9513)
- Paola Neri (ORCID: https://orcid.org/0000-0002-2595-3647)
- Kim De Veirman (ORCID: https://orcid.org/0000-0002-1313-6121)
- Yannick De Vlaeminck (ORCID: https://orcid.org/0000-0002-1882-4740)
- Nicola Giuliani (ORCID: https://orcid.org/0000-0003-3457-3774)
- Fien Meeus (ORCID: https://orcid.org/0000-0002-5866-2002)
- Chenggong Tu (ORCID: https://orcid.org/0000-0001-9281-5298)
- Janne Billiau
- Marta Marco Aragon
- Lauren van den Broecke
- Fenja Watté
Institutions
- University of Parma (IT)
- Vrije Universiteit Brussel (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13045-025-01756-5
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Fonds Wetenschappelijk Onderzoek
- Università degli Studi di Parma
- Koning Boudewijnstichting
- Kom op tegen Kanker
- Vlaamse regering
- Fondation contre le Cancer