Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence
MGO-induced glycation stress contributes to aortic stiffening and glycation stress lowering compounds hold promise for mitigating these effects.
Authors
- Ravinandan Venkatasubramanian
- Sophia Mahoney (ORCID: https://orcid.org/0000-0002-0013-4514)
- Kiyomi R. Kaneshiro (ORCID: https://orcid.org/0000-0003-0636-7455)
- Marcela Vargas Trujillo
- Katelyn R. Ludwig (ORCID: https://orcid.org/0009-0005-0592-2711)
- Alice Zhang (ORCID: https://orcid.org/0000-0001-5094-6898)
- Richmond Sarpong
- Zachary S. Clayton (ORCID: https://orcid.org/0000-0003-3878-3533)
- Muniesh Muthaiyan Shanmugam (ORCID: https://orcid.org/0000-0001-8018-2032)
- Lauren Wimer (ORCID: https://orcid.org/0009-0009-2104-9501)
- James J. Galligan (ORCID: https://orcid.org/0000-0001-7882-5596)
- Pankaj Kapahi (ORCID: https://orcid.org/0000-0002-5629-4947)
- Mary A. Darrah
- Edgard Morazan
- Douglas R. Seals
- Parminder Singh
- Lizbeth Enriquez Najera
Institutions
- Buck Institute for Research on Aging (US)
- University of Arizona (US)
- University of Colorado Boulder (US)
- University of Colorado Anschutz Medical Campus (US)
- Berea College (US)
Publication Details
- Journal
- Aging
- Published
- 2025-11-14
- DOI
- https://doi.org/10.18632/aging.206335
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Larry L. Hillblom Foundation
- National Institutes of Health