Pancreatic Ductal Adenocarcinoma After Hepatitis C Infection
In this cohort study of veterans, chronic HCV infection was associated with a 1.8-fold higher risk of PDAC diagnosis, and HCV genotypes 3 and 1 had greater PDAC risk than genotype 2. These findings prompt future research on the mechanisms underlying this association and the impact of HCV treatment on PDAC risk.
Authors
- Catherine Mezzacappa (ORCID: https://orcid.org/0000-0001-7181-6902)
- Amy C. Justice (ORCID: https://orcid.org/0000-0003-0139-5502)
- Lesley S. Park (ORCID: https://orcid.org/0000-0002-3848-7753)
- Cynthia Brandt (ORCID: https://orcid.org/0000-0001-8179-1796)
- Yu‐Xiao Yang (ORCID: https://orcid.org/0000-0002-3690-9174)
- Gyanprakash A. Ketwaroo (ORCID: https://orcid.org/0000-0001-9357-6401)
- Rachel N. Levinson
- Melissa Skanderson (ORCID: https://orcid.org/0000-0002-5539-8680)
- Kevin M. Schuster (ORCID: https://orcid.org/0000-0003-3773-8124)
- Louise Wang (ORCID: https://orcid.org/0000-0002-9261-8371)
- Janet P. Tate
- Ryan Bushman
Institutions
- Palo Alto University (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.43701
- Primary Topic
- Hepatitis C virus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yale University