Modulating effects of microbiota on synbiotic intervention outcomes for microbiota-derived trimethylamine, trimethylamine N-oxide and indoxyl sulfate in healthy young medical students: insights from a 12-week randomized clinical trial
In this randomized, placebo-controlled trial in healthy young adults, the synbiotic did not produce a significant arm-wide effect on post-challenge serum TMA, TMAO, or indoxyl sulfate over 12 weeks. Exploratory moderation analyses suggest that baseline gut-microbiota features, taxonomic and functional, may modulate individual responses, particularly for IS and TMA, supporting a precision-nutrition framework. The translational significance of this study stems from the observation that primary prevention, which is particularly important in metabolic diseases, should be individualised based on the function of the microbiota.
Authors
- Mariusz Kaczmarczyk
- Karolina Kędzierska-Kapuza (ORCID: https://orcid.org/0000-0001-5853-2147)
- Konrad Podsiadło (ORCID: https://orcid.org/0000-0002-4061-2103)
- Karolina Skonieczna‐Żydecka (ORCID: https://orcid.org/0000-0002-3430-9079)
- Igor Łoniewski (ORCID: https://orcid.org/0000-0002-5398-4985)
- Emilia Samborowska (ORCID: https://orcid.org/0000-0002-0646-0847)
- Danuta Cembrowska-Lech (ORCID: https://orcid.org/0000-0002-1503-0064)
- Urszula Szkudlarek (ORCID: https://orcid.org/0000-0003-3113-3060)
- Kazimierz Ciechanowski (ORCID: https://orcid.org/0000-0003-2758-8871)
- Kacper Lechowicz (ORCID: https://orcid.org/0000-0002-0807-8510)
- Anna Surówka (ORCID: https://orcid.org/0000-0002-8693-9259)
- Sylwester Drożdżal (ORCID: https://orcid.org/0000-0002-4082-2696)
- Mariusz Buszman
Institutions
- University of Szczecin (PL)
- Zachodniopomorska Szkoła Biznesu w Szczecinie (PL)
- Park-Klinik Weißensee (DE)
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- Ministry of Interior and Administration (PL)
- Pomeranian Medical University (PL)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s12967-025-07345-x
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pomorski Uniwersytet Medyczny W Szczecinie