Temporal dynamic of cognitive decline in type 2 diabetes mellitus patients: a multimodal biomarker analysis using event-based modal and principal component analysis
Memory decline and insular gyrus atrophy may serve as early biomarkers for T2DM-related cognitive impairment. These findings highlight potential targets for early intervention and suggest strategies for developing personalized treatments to improve life quality in affected individuals.
Authors
- Min-Hua Ni
- Yao Tong (ORCID: https://orcid.org/0000-0002-6987-8853)
- Guang-Bin Cui (ORCID: https://orcid.org/0000-0002-6908-0788)
- Yan Cui (ORCID: https://orcid.org/0000-0002-7577-6845)
- Xiaofeng Yu (ORCID: https://orcid.org/0000-0001-6742-3591)
- Ziyang Ma
- Bin Gao (ORCID: https://orcid.org/0000-0003-3377-6895)
- Xinyu Cao (ORCID: https://orcid.org/0000-0001-8032-4029)
- Sining Li (ORCID: https://orcid.org/0000-0001-5260-4015)
- Pan Dai
- Bo Hu (ORCID: https://orcid.org/0000-0002-1135-0669)
- Li-Juan Du
- Hao Xie (ORCID: https://orcid.org/0009-0008-0904-0953)
- Xiaoyan Bai (ORCID: https://orcid.org/0000-0003-0697-4378)
- Ying Yu (ORCID: https://orcid.org/0000-0002-6537-5159)
- Lin-Feng Yan
Institutions
- Tang Du Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1186/s13098-025-02003-0
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China